MACRO-COSTING OF THE USE OF BORTEZOMIB IN THE TREATMENT OF MULTIPLE MYELOMA FROM THE PERSPECTIVE OF THE SUS

Abstract

Introduction: Bortezomib is one of the most widely used medications in the treatment of multiple myeloma (MM). Objective: To conduct a macro-costing study of the use of bortezomib in the treatment of MM from the perspective of the Unified Health System (SUS). Methods: Direct costs related to the acquisition of bortezomib were considered. The annual incidence of MM cases and the estimated number of patients undergoing treatment were calculated using data from the Department of Information Technology of the Unified Health System (DATASUS). The cost of bortezomib was obtained from the Health Price Database - BPS. The approximate cost per patient was compared to the amount reimbursed by the Outpatient Procedure Authorization (APAC). Two treatment possibilities were considered: 9 cycles, used for patients who are candidates for autologous hematopoietic stem cell transplantation (ASCT) (30% of the population), and 12 cycles used for patients who are not candidates for ASCT (70%). Results: Considering 1.3mg/m and 1.5mg/m, and a dose wastage of 10%, the cost per patient in 9 cycles was R$17,678.30 and R$18,023.64, respectively. For 12 cycles the cost was R$23,569.94 for a dose of 1.3mg/m and R$24,030.39 for a dose of 1.5mg/m. According to the current APAC value, which is R$5,224.65, the total amount paid for the treatment of 9 cycles is R$47,021.85 and for 12 cycles it is R$62,695.80. Discussion and Conclusion: The average cost of treatment with bortezomib per patient was R$22,100.59, and the amount reimbursed by APAC was R$57,993.62. However, it is emphasized that only the direct costs of acquiring bortezomib were computed.