Tutorial on Physiology-based Pharmacokinetic (PBPK) Modeling in an Open Access Program

Resumo

Objectives: To broaden the study of PBPK (Physiology-based Pharmacokinetic) modeling
for Portuguese-speaking professionals and students by developing a basic simple
PBPK modeling tutorial using free access software. Methods: Descriptive study for the
development of a Portuguese tutorial dedicated to the use of the PK-Sim® software
(version 11.2). Results: A tutorial was developed in PK-Sim®, entirely in Portuguese,
which enables individuals interested in Pharmacometrics to perform a PBPK analysis
in order to study and predict the pharmacokinetics of drugs based on the physiological
and anatomical characteristics of a population of interest, as well as the physical and
chemical properties of a specific drug. Conclusions: Considering the importance of
health technologies and their subsequent assessment, this tutorial proves as a relevant
tool, both for research and development and for clinical practice, as well as leveraging
the democratization of the teaching and research of Pharmaceutical Sciences among
Portuguese-speaking people.